11/15/2023 0 Comments Retin a 0.1![]() These effects are mediated by tretinoin's interaction with a family of nuclear retinoic receptors. Through these actions, the comedo contents are extruded and the formation of the microcomedo, the precursor lesion of acne vulgaris, is reduced.Īdditionally, tretinoin acts by modulating the proliferation and differentiation of epidermal cells. By increasing the mitotic activity of follicular epithelia, tretinoin also increases the turnover rate of thin, loosely-adherent corneocytes. Tretinoin promotes detachment of cornified cells and the enhanced shedding of corneocytes from the follicle. Comedones form in follicles with an excess of keratinized epithelial cells. Tretinoin has the following structure:Īlthough the exact mode of action of tretinoin is unknown, current evidence suggests that the effectiveness of tretinoin in acne is due primarily to its ability to modify abnormal follicular keratinization. Tretinoin has a molecular weight of 300.44. It is a member of the retinoid family of compounds, and a metabolite of naturally occurring Vitamin A. Other components of this formulation are purified water, carbomer 974P (0.04% formulation), carbomer 934P (0.1% formulation), glycerin, disodium EDTA, propylene glycol, sorbic acid, PPG-20 methyl glucose ether distearate, cyclomethicone and dimethicone copolyol, benzyl alcohol, trolamine, and butylated hydroxtoluene.Ĭhemically, tretinoin is all- trans-retinoic acid, also known as (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. This formulation uses patented methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE® System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Retin-A Micro ® (tretinoin gel) microsphere, 0.1% and 0.04%, is a formulation containing 0.1% or 0.04%, by weight, tretinoin for topical treatment of acne vulgaris. ![]()
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